Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation-Reference-Cited by-同舟云学术

Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin, cellular adherence, and embryonic gastrulation

Published:2020-02-01 Issue:3 Volume:31 Page:167-183
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Graham Jill B.¹²,Sunryd Johan C.¹²,Mathavan Ketan²³,Weir Emma²³,Larsen Ida Signe Bohse⁴⁵,Halim Adnan⁴⁵,Clausen Henrik⁴⁵,Cousin Hélène²³,Alfandari Dominque²³,Hebert Daniel N.¹²

Affiliation:

1. Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Amherst, MA 01003

2. Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Amherst, MA 01003

3. Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Amherst, MA 01003

4. Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen 2200, Denmark

5. Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen 2200, Denmark

Abstract

Here we characterize TMTC3 as an ER, polytopic membrane protein with C-terminal luminal-facing TPRs, and an O-mannosyltransferase of E-cadherin. O-mannosylation of cadherins by TMTC3 affects cellular adherence, E-cadherin homophilic binding, and embryonic gastrulation, helping to explain the basis of a number of TMTC3-associated disease variants.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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