Loss of a conserved MAPK causes catastrophic failure in assembly of a specialized cilium-like structure inToxoplasma gondii-Reference-Cited by-同舟云学术

Loss of a conserved MAPK causes catastrophic failure in assembly of a specialized cilium-like structure inToxoplasma gondii

Published:2020-04-15 Issue:9 Volume:31 Page:881-888
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

O’Shaughnessy William J.¹,Hu Xiaoyu¹,Beraki Tsebaot¹,McDougal Matthew²,Reese Michael L.¹³

Affiliation:

1. Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390

2. Department of Microbiology, UT Southwestern Medical Center, Dallas, TX 75390

3. Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390

Abstract

Toxoplasma gondii that lacks the kinase ERK7 cannot invade or egress from their host cells, thereby blocking their replicative cycle. These defects are due to the loss of a specialized cilium-like structure called the conoid. Strikingly, the ultrastructural changes are specific to the conoid, and suggest an important role for ERK7 in its biogenesis.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference40 articles.

1. ULTRASTRUCTURE OF THE PELLICULAR COMPLEX OF PLASMODIUM FALLAX

2. Cytoskeleton Assembly in Toxoplasma gondii Cell Division

3. Ancient MAPK ERK7 is regulated by an unusual inhibitory scaffold required for Toxoplasma apical complex biogenesis

4. The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism

5. Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii

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