TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K–C2α-, and INPP4B-mediated phosphoinositide conversions-Reference-Cited by-同舟云学术

TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K–C2α-, and INPP4B-mediated phosphoinositide conversions

Published:2020-03-01 Issue:5 Volume:31 Page:360-372
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Aki Sho¹,Yoshioka Kazuaki¹,Takuwa Noriko²,Takuwa Yoh¹

Affiliation:

1. Department of Physiology, Kanazawa University School of Medicine, Kanazawa, Ishikawa 920-8640, Japan

2. Department of Health Science, Ishikawa Prefectural University, Kahoku, Ishikawa 929-1210, Japan

Abstract

TGFβ activates the sequential phosphoinositide conversions mediated by class II PI3K-C2α, the 5′-phosphatse synaptojanin1, and the 4′-phosphatase INPP4B with the coordinated interactions of the enzymes controlled by ALK5. The phosphoinositide conversions play an essential role in TGFβ receptor endocytosis and its endosomal Smad signaling.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference46 articles.

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4. Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells

5. Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

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