Nonmuscle myosin IIB is a driver of cellular reprogramming-Reference-Cited by-同舟云学术

Nonmuscle myosin IIB is a driver of cellular reprogramming

Published:2023-06-01 Issue:7 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Balaban Amanda E.¹,Nguyen Ly T. S.¹,Parajón Eleana¹,Robinson Douglas N.¹²³^ORCID

Affiliation:

1. Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

2. Departments of Pharmacology and Molecular Sciences, Medicine, and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205

3. Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218

Abstract

To test the impact of engineering cells with altered contractile properties, NMIIB and mutants that have different assembly and force-generating properties were introduced. Adding NMIIB into pancreatic ductal epithelia–derived cancer cells led to altered cell morphology. Additionally, NMIIB is highly integrated with a range of cellular systems, including metabolism and gene expression. Modifying the contractile machinery leads to cellular reprogramming.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference39 articles.

1. Deregulated homeobox gene expression in cancer: cause or consequence?

2. Linking E-cadherin mechanotransduction to cell metabolism through force-mediated activation of AMPK

3. Nonmuscle Myosin II Isoforms Coassemble in Living Cells

4. A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

5. Matrix Elasticity Directs Stem Cell Lineage Specification

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