Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin-Reference-Cited by-同舟云学术

Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin

Published:2022-08-01 Issue:9 Volume:33 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Kennedy Andrew¹^ORCID,Ren Hong Yu¹,Madden Victoria J.²,Cyr Douglas M.¹

Affiliation:

1. Department of Cell Biology and Physiology, School of Medicine, and

2. Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

Abstract

P23H-rhodopsin accumulates in an ERAD-resistant conformation that is stabilized by DNAJB12 and Hsp70. DNAJB12 and FIP200 colocalize on the rim of omegasomes to which lysosomes dock during disposal of dominantly toxic P23H-rhodopsin.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference66 articles.

1. TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

2. The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy

3. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

4. Curvature induction and membrane remodeling by FAM134B reticulon homology domain assist selective ER-phagy

5. ERQC Autophagy: Yet Another Way to Die

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Retinal light damage: From mechanisms to protective strategies;Survey of Ophthalmology;2024-11

2. J-domain proteins: From molecular mechanisms to diseases;Cell Stress and Chaperones;2024-02

3. In vivo identification of Drosophila rhodopsin interaction partners by biotin proximity labeling;Scientific Reports;2024-01-23

4. The generation of detergent-insoluble clipped fragments from an ERAD substrate in mammalian cells;Scientific Reports;2023-12-06

5. TOLLIP acts as a cargo adaptor to promote lysosomal degradation of aberrant ER membrane proteins;The EMBO Journal;2023-11-06