Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins-Reference-Cited by-同舟云学术

Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins

Published:2023-07-01 Issue:8 Volume:34 Page:
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Peifer Mark¹,Schmidt Anja¹,Finegan Tara²,Häring Matthias³⁴⁵⁶,Kong Deqing⁷,Fletcher Alexander G.⁸,Alam Zuhayr¹,Grosshans Jörg⁷,Wolf Fred³⁴⁵⁶

Affiliation:

1. Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280

2. Department of Biology, University of Rochester, Rochester, New York 14627-0211

3. Göttingen Campus Institute for Dynamics of Biological Networks, Georg August University, 37075 Göttingen, Germany

4. Max Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany

5. Max Planck Institute for Multidisciplinary Sciences, 37075 Göttingen, Germany

6. Institute for Dynamics of Complex Systems, Georg August University, 37077 Göttingen, Germany

7. Department of Biology, Philipps University, 35043 Marburg, Germany

8. School of Mathematics and Statistics and Bateson Centre, University of Sheffield, Sheffield S10 2TN, United Kingdom

Abstract

The dramatic cell shape changes and movements of embryonic development require robust but dynamic linkage between cell-cell adherens junctions and the force-generating actomyosin cytoskeleton. Schmidt et al. combine genetic analysis and high resolution imaging to define the mechanism of action and function of Drosophila Polychaetoid, homolog of mammalian ZO-1, and reveal new insights into the complex molecular architecture of adherens junctions.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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