F-actin–rich territories coordinate apoptosome assembly and caspase activation during DNA damage–induced intrinsic apoptosis

Abstract

DNA damage–induced apoptosis relies on signaling platforms called apoptosomes and the activation of caspase proteases, but how their activities are coordinated in cells is not well understood. The cytoskeleton assembles into an F-actin–rich territory that couples the apoptosome biogenesis process to the initiation of caspase activation.