A fine balance among key biophysical factors is required for recovery of bipolar mitotic spindle from monopolar and multipolar abnormalities

Author:

Li Xiaochu12,Bloomfield Mathew13ORCID,Bridgeland Alexandra34,Cimini Daniela13ORCID,Chen Jing135ORCID

Affiliation:

1. Department of Biological Sciences, Virginia Tech, Virginia Tech, Blacksburg, VA 24061

2. BIOTRANS Graduate Program, Virginia Tech, Virginia Tech, Blacksburg, VA 24061

3. Fralin Life Sciences Institute, Virginia Tech, Virginia Tech, Blacksburg, VA 24061

4. Systems Biology Program, College of Science, Virginia Tech, Virginia Tech, Blacksburg, VA 24061

5. Center for Soft Matter and Biological Physics, Virginia Tech, Virginia Tech, Blacksburg, VA 24061

Abstract

A biophysical model was developed for centrosome movement during mitotic–spindle assembly to investigate how a cell manages to separate and cluster its centrosomes depending on needs to achieve bipolar spindle formation. The model provides explanation for related experimental phenomena and mechanistic insights into robust spindle bipolarization.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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