A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase

Author:

Ruan Jingjing12,Liang Dongdong3,Yan Wenjing1,Zhong Yongwang1,Talley Daniel C.4,Rai Ganesha4,Tao Dingyin4,LeClair Christopher A.4,Simeonov Anton4,Zhang Yinghua5,Chen Feihu6,Quinney Nancy L.7,Boyles Susan E.7,Cholon Deborah M.7,Gentzsch Martina789,Henderson Mark J.4,Xue Fengtian3,Fang Shengyun1ORCID

Affiliation:

1. Center for Biomedical Engineering and Technology, Department of Physiology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201

2. First Affiliated Hospital and

3. University of Maryland School of Pharmacy, Baltimore, MD 21201

4. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850

5. Center for Innovative Biomedical Resources, Biosensor Core, University of Maryland School of Medicine, Baltimore, MD 21201

6. School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, China

7. Marsico Lung Institute and Cystic Fibrosis Research Center

8. Department of Pediatric Pulmonology, and

9. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

Abstract

RNF5 has multiple biological roles and has been linked to the development of severe diseases such as cystic fibrosis, acute myeloid leukemia, and certain viral infections. This study developed a small molecule inhibitor and degrader of the RNF5 ubiquitin ligase, providing a chemical biology tool for RNF5 research and therapeutic development.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

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