Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets-Reference-Cited by-同舟云学术

Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets

Published:2020-05-01 Issue:10 Volume:31 Page:1047-1059
ISSN:1059-1524
Container-title:Molecular Biology of the Cell
language:en
Short-container-title:MBoC

Author:

Yue Lambert¹,McPhee Michael J.²,Gonzalez Kevin¹,Charman Mark²,Lee Jonghwa²,Thompson Jordan²,Winkler Dirk F. H.³,Cornell Rosemary B.⁴,Pelech Steven¹³,Ridgway Neale D.²

Affiliation:

1. Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC V6T 2B5, Canada

2. Department of Pediatrics and Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H 4R2, Canada

3. Kinexus Bioinformatics Corporation, Vancouver, BC V6P 6T3, Canada

4. Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada

Abstract

The translocation of CCTα, the rate-limiting enzyme for phosphatidylcholine synthesis, to nuclear membranes and nuclear lipid droplets results in reversible dephosphorylation of S319 and sustained phosphorylation of Y359+S362. Independent regulation of these phosphosites in the P-domain of CCTα is required for activation on nuclear membranes.

Publisher

American Society for Cell Biology (ASCB)

Subject

Cell Biology,Molecular Biology

Reference58 articles.

1. Nuclear-localized CTP:phosphocholine cytidylyltransferase α regulates phosphatidylcholine synthesis required for lipid droplet biogenesis

2. Lipid Regulation of CTP:Phosphocholine Cytidylyltransferase: Electrostatic, Hydrophobic, and Synergistic Interactions of Anionic Phospholipids and Diacylglycerol

3. Binding of CTP:Phosphocholine Cytidylyltransferase to Lipid Vesicles: Diacylglycerol and Enzyme Dephosphorylation Increase the Affinity for Negatively Charged Membranes

4. ras-induced Up-regulation of CTP:Phosphocholine Cytidylyltransferase α Contributes to Malignant Transformation of Intestinal Epithelial Cells

5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome

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