Development and anatomo-physiological features of kidneys in premature newborns

Abstract

A premature baby in need of resuscitation after birth is exposed to damaging factors that affect the entire body, including the kidneys. The review considers the stages of development and identifies the main anatomical and physiological features of the kidneys in premature babies. The main risk factor for the development of pathology associated with immaturity of the kidneys in preterm infants is imperfect glomerular and tubular functions of the kidneys, a large capillary surface of the kidneys, high renal blood flow, imperfect regulation of the acid-base balance, and the ability to concentrate, which become untenable under the influence of external loads. Any damaging factor in the antenatal period in premature infants, considering the anatomical and physiological characteristics and the imperfect compensatory response from the kidneys, can permanently change the structure of the kidneys, which will lead to the development of chronic kidney disease in the future. Proper management of premature newborns, considering the anatomical and physiological characteristics of the kidneys, will significantly reduce the risk of severe complications and mortality among premature newborns, and improve the long-term clinical prognosis in such children.