Affiliation:
1. Voyno-Yasenetsky Krasnoyarsk State Medical University
Abstract
Objective. To analyze the results of clinical and laboratory studies of children born to women with syphilitic infection, and select the most clinically significant criteria to optimize the diagnosis of early congenital syphilis. Methods. A comprehensive clinical and laboratory examination of 547 newborns born to women with a syphilitic infection. Results. The diagnostic sensitivity of the enzyme immunoassay with the determination of specific IgM was 86.6%, the polymerase chain reaction with the detection of Treponema pallidum DNA was 91.6%. Conclusion. The examination of newborns from mothers with a syphilitic infection can be optimized by reducing the number of laboratory techniques (microprecipitation reaction and passive haemagglutination reaction), subject to the mandatory determination of specific IgM and IgG in the first day of life, followed by further confirmation of diagnostics (IgG titer dynamics and the determination of the presence of T. pallidum DNA, as well as instrumental methods of research).
Publisher
The National Academy of Pediatric Science and Innovation
Subject
Pediatrics, Perinatology and Child Health
Reference20 articles.
1. Kubanova A.A., Kubanov A.A., Melekhina L.E. The Incidence of syphilis in the Russian Federation for the period 2006 – 2016. Vestnik dermatologii i venerologii 2017; 5: 16–25. (in Russ)
2. Federal clinical practice guidelines for the management of patients with syphilis. Мoscow, 2015; 45. (in Russ)
3. Dmitriev A.V., Tkachenko T.G., Fedina N.V., Shatskaya E.E. Early congenital syphilis: epidemiological characteristics and clinical options. Neonatologiya: novosti, mneniya, obuchenie 2016; 2: 103–107. (in Russ)
4. Chebotarev V.V., Chebotareva N.V., Ashakov M.S. Syphilis: was it predictable situation? Medicus 2015; 1: 12–14. (in Russ)
5. Gupta R., Vora R.V. Congenital syphilis, still a reality. Indian J Sex Transm Dis 2013 34(1): 50–52. DOI: 10.4103/0253-7184.112941