Affiliation:
1. Morozov Children’s City Hospital
2. Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University
3. Morozov Children’s City Hospital; Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University
Abstract
Among the wide variety of tree nuts, walnut is an allergen that deserves special attention in the context of acute allergic reactions, due to their severity, low inducing trigger dose, and minimal likelihood of developing tolerance. The overall consumption of walnut has been steadily increasing, while the importance of this allergen as a trigger for anaphylaxis is underestimated due to its often “hidden” presence in foods and the difficulty of trigger verification. This article presents the epidemiological aspects of walnut food allergy, provides current data on the molecular characteristics and properties of various allergen proteins, and their clinical significance for the development of anaphylaxis. The article is supplemented with two clinical cases of food anaphylaxis to walnuts from own clinical practice.
Publisher
The National Academy of Pediatric Science and Innovation
Subject
Pediatrics, Perinatology and Child Health
Reference40 articles.
1. McWilliam V., Koplin J., Lodge C., Tang M., Dharmage S., Allen K. The Prevalence of Tree Nut Allergy: A Systematic Review. Curr Allergy Asthma Rep 2015; 15(9): 54. DOI: 10.1007/s11882–015–0555–8
2. Poowuttikul P., Seth D. Anaphylaxis in Children and Adolescents. Pediatr Clin North Am 2019; 66(5): 995–1005. DOI: 10.1016/j.pcl.2019.06.005
3. Pampura A.N., Esakova N.V. Pediatric anaphylaxis: unresolved issues of diagnosis and patient management. Rossijskij allergologicheskij zhurnal 2021; 18(3): 131–136. (in Russ.) DOI: 10.36691/RJA1482
4. Esakova N.V., Treneva M.S., Okuneva T.S., Pampura A.N. Food Anaphylaxis: Reported Cases in Russian Federation Children. Am J Public Health Res 2015; 5: 187–191. DOI: 10.12691/ajphr-3–5–2
5. Blankestijn M.A., Remington B.C., Houben G.F., Baumert J.L., Knulst A.C., Blom W.M. et al. Threshold Dose Distribution in Walnut Allergy. J Allergy Clin Immunol Pract 2017; 5(2): 376–380. DOI: 10.1016/j.jaip.2016.12.005