A Rare Case of Angioimmunoblastic T-Cell Lymphoma with Pleomorphic Cutaneous Manifestations

Abstract

Angioimmunoblastic T-cell lymphoma is a type of mature T-cell lymphoma that is characterised by a range of symptoms including fever, night sweats, weight loss, swollen lymph nodes, enlarged liver and spleen, high white blood cell count, immune system dysfunction, fluid accumulation in the chest and abdomen and edema. The skin may also be affected, with various types of lesions and tumours such as maculopapular, urticarial, vesicular and nodular. Diagnosis requires a lymph node biopsy and immunohistochemistry, as the histological changes are typically subtle. This case is being presented to increase awareness of this rare and unique lymphoma, which can have a variety of skin symptoms and modest abnormalities that can make diagnosis difficult in clinical practice. To properly diagnose and stage the disease, additional tests such as histological assessment and immunohistochemistry are necessary.