Gene Context and DNA Rearrangements in the Carbapenemase Locus of Division II Strains of Bacteroides fragilis-Reference-Cited by-同舟云学术

Gene Context and DNA Rearrangements in the Carbapenemase Locus of Division II Strains of Bacteroides fragilis

Published:2009-06 Issue:6 Volume:53 Page:2677-2678
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

García Nuria¹,Gutiérrez Gloria²,Lorenzo María¹,Vadillo Santiago¹,Píriz Segundo¹,Quesada Alberto²

Affiliation:

1. Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura, Avenida de la Universidad s/n, 10071-Cáceres, Spain

2. Departamento de Bioquímica

Abstract

ABSTRACT The cfiA gene is clustered in a bicistronic operon encoding an N -acetyltransferase and an O -acetyltransferase related to resistance markers. This genetic context, exclusively found in strains of Bacteroides fragilis division II, has been highly rearranged by the successive integration of two new mobile sequences, a miniature element and IS Bf9 . Besides that, among the DNA polymorphisms detected in the cfiA locus, only the integration of IS 942 at its promoter was a determinant for expression of carbapenemase activity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01514-08

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