Fluoroquinolone versus Beta-Lactam Oral Step-Down Therapy for Uncomplicated Streptococcal Bloodstream Infections-Reference-Cited by-同舟云学术

Fluoroquinolone versus Beta-Lactam Oral Step-Down Therapy for Uncomplicated Streptococcal Bloodstream Infections

Published:2020-10-20 Issue:11 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Arensman Kellie¹,Shields Maureen²,Beganovic Maya¹,Miller Jessica L.³⁴,LaChance Erik⁵,Anderson Morgan⁶⁷,Dela-Pena Jennifer¹^ORCID

Affiliation:

1. Department of Pharmacy, Advocate Lutheran General Hospital, Park Ridge, Illinois, USA

2. Russell Center for Research and Innovation, Park Ridge, Illinois, USA

3. Department of Pharmacy, Advocate South Suburban Hospital, Hazel Crest, Illinois, USA

4. Department of Pharmacy, Advocate Trinity Hospital, Chicago, Illinois, USA

5. Department of Pharmacy, Advocate Illinois Masonic Medical Center, Chicago, Illinois, USA

6. Department of Pharmacy, Advocate Condell Medical Center, Libertyville, Illinois, USA

7. Department of Pharmacy, Advocate Good Shepherd Hospital, Barrington, Illinois, USA

Abstract

Fluoroquinolones (FQs) are often preferred as oral step-down therapy for bloodstream infections (BSIs) due to favorable pharmacokinetic parameters; however, they are also associated with serious adverse events. The objective of this study was to compare clinical outcomes for patients who received an oral FQ versus an oral beta-lactam (BL) as step-down therapy for uncomplicated streptococcal BSIs. This multicenter, retrospective cohort study analyzed adult patients who completed therapy with an oral FQ or BL with at least one blood culture positive for a Streptococcus species from 1 January 2014 to 30 June 2019.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01515-20

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