Decyl Gallate as a Possible Inhibitor of N-Glycosylation Process in Paracoccidioides lutzii-Reference-Cited by-同舟云学术

Decyl Gallate as a Possible Inhibitor of N-Glycosylation Process in Paracoccidioides lutzii

Published:2019-11 Issue:11 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

de Paula e Silva Ana Carolina Alves¹^ORCID,de Oliveira Haroldo Cesar¹,Scorzoni Liliana¹,Marcos Caroline Maria¹,Santos Claudia Tavares dos¹,Fusco-Almeida Ana Marisa¹,Salina Ana Carolina Guerta²³,Medeiros Alexandra Ivo²,Almeida Fausto⁴,Li Sheena Claire⁵⁶,Boone Charles⁵,Mendes-Giannini Maria J. S.¹

Affiliation:

1. Department of Clinical Analysis, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil

2. Department of Biological Sciences, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara, São Paulo, Brazil

3. Department of Biochemistry and Immunology, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

4. Department of Cellular/Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil

5. Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada

6. RIKEN Center for Sustainable Resource Science, Saitama, Japan

Abstract

The available antifungal therapeutic arsenal is limited. The search for alternative drugs with fewer side effects and new targets remains a major challenge. Decyl gallate (G14) is a derivative of gallic acid with a range of biological activities and broad-spectrum antifungal activity. Previously, our group demonstrated the promising anti- Paracoccidioides activity of G14.

Funder

Rede Nacional de Métodos Alternativos - Conselho Nacional de Pesquisa e Desenvolvimento

Fundação de Amparo a Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoa de Nivel Superior

Programa de Doutorado Sanduíche no Experior

Programa de Apoio ao Desenvolvimento Ciêntifíco da Faculdade de Ciências Farmacêuticas da UNESP

Pró-reitoria de Pesquisa da UNESP

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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