Independent Translocation of Two Micronemal Proteins in Developing Plasmodium falciparum Merozoites-Reference-Cited by-同舟云学术

Independent Translocation of Two Micronemal Proteins in Developing Plasmodium falciparum Merozoites

Published:2002-10 Issue:10 Volume:70 Page:5751-5758
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Healer Julie¹,Crawford Simon²,Ralph Stuart²,McFadden Geoff²,Cowman Alan F.¹

Affiliation:

1. The Walter and Eliza Hall Institute of Medical Research

2. School of Botany, University of Melbourne, Melbourne, Australia

Abstract

ABSTRACT Apical membrane antigen 1 of Plasmodium falciparum (PfAMA1) contains an N-terminal propeptide that is removed prior to the translocation of the mature protein onto the merozoite surface. We localized unprocessed PfAMA1 to the microneme organelles of the intraerythrocytic schizont. The results have suggested that the processed form of PfAMA1 translocates from the microneme compartment independently of another microneme protein, EBA175, which is also involved in the invasion of human erythrocytes.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.70.10.5751-5758.2002

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