Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis-Reference-Cited by-同舟云学术

Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

DiVenere Andrea M.¹,Amengor Dzifa²,Silva Rui P.²,Goldsmith Jory A.²,McLellan Jason S.²³^ORCID,Maynard Jennifer A.¹³^ORCID

Affiliation:

1. Department of Chemical Engineering, University of Texas, Austin, Texas, USA

2. Department of Molecular Biosciences, University of Texas, Austin, Texas, USA

3. LaMontagne Center for Infectious Disease, University of Texas, Austin, Texas, USA

Abstract

Despite high vaccine coverage in developed countries, the incidence of pertussis has increased in recent decades, often leading to severe consequences for sensitive groups, including infants. For this reason, improving the efficacy of pertussis vaccines is critical, and the addition of new antigens is a leading strategy to achieve this goal.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Welch Foundation

National Science Foundation

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01527-22

Reference69 articles.

1. Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase