The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia-Reference-Cited by-同舟云学术

The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia

Published:2022-08-30 Issue:4 Volume:13 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Wang Chuangqi¹,Li Yijia²³,Kaplonek Paulina⁴,Gentili Matteo⁵,Fischinger Stephanie⁴,Bowman Kathryn A.²³⁴,Sade-Feldman Moshe⁵,Kays Kyle R.³,Regan James²,Flynn James P.²,Goldberg Marcia B.³⁵⁶,Hacohen Nir⁵^ORCID,Filbin Michael R.²⁵^ORCID,Lauffenburger Douglas A.¹^ORCID,Alter Galit³⁴^ORCID,Li Jonathan Z.²

Affiliation:

1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

2. Brigham and Women’s Hospital, Boston, Massachusetts, USA

3. Massachusetts General Hospital, Boston, Massachusetts, USA

4. Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA

5. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

6. Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA

Abstract

We showed that persistent SARS-CoV-2 RNAemia is an independent predictor of severe COVID-19. We observed that SARS-CoV-2-targeted antibody maturation, specifically Fc-effector functions rather than neutralization, was strongly linked with the ability to rapidly clear viremia.

Funder

Mark and Lisa Schwartz

NIH

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.01577-22

Reference40 articles.

1. SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes

2. Detectable Serum Severe Acute Respiratory Syndrome Coronavirus 2 Viral Load (RNAemia) Is Closely Correlated With Drastically Elevated Interleukin 6 Level in Critically Ill Patients With Coronavirus Disease 2019