Disruption of the Cytoplasmic Membrane Structure and Barrier Function Underlies the Potent Antiseptic Activity of Octenidine in Gram-Positive Bacteria-Reference-Cited by-同舟云学术

Disruption of the Cytoplasmic Membrane Structure and Barrier Function Underlies the Potent Antiseptic Activity of Octenidine in Gram-Positive Bacteria

Published:2022-05-24 Issue:10 Volume:88 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Malanovic Nermina¹^ORCID,Buttress Jessica A.²,Vejzovic Djenana¹,Ön Ayse¹,Piller Paulina¹,Kolb Dagmar³⁴,Lohner Karl¹³,Strahl Henrik²^ORCID

Affiliation:

1. Institute of Molecular Biosciences, Biophysics Division, University of Graz, Graz, Austria

2. Centre for Bacterial Cell Biology, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom

3. BioTechMed Graz, Graz, Austria

4. Core Facility Ultrastructure Analysis, Center for Medical Research, Medical University of Graz, Graz, Austria

Abstract

OCT is a well-established antiseptic molecule routinely used in a large field of clinical applications. Since the spread of antimicrobial resistance has restricted the use of antibiotics worldwide, topically applied antiseptics like OCT, with a broad spectrum of antimicrobial activity and high safety profile, gain increasing importance for effective infection prevention and therapy.

Funder

UK Medical Research Council

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.00180-22

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