A Complete Genome Screening Program of Clinical Methicillin-Resistant Staphylococcus aureus Isolates Identifies the Origin and Progression of a Neonatal Intensive Care Unit Outbreak-Reference-Cited by-同舟云学术

A Complete Genome Screening Program of Clinical Methicillin-Resistant Staphylococcus aureus Isolates Identifies the Origin and Progression of a Neonatal Intensive Care Unit Outbreak

Published:2019-12 Issue:12 Volume:57 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Sullivan Mitchell J.¹²,Altman Deena R.¹³^ORCID,Chacko Kieran I.¹²,Ciferri Brianne¹²,Webster Elizabeth¹²,Pak Theodore R.¹²^ORCID,Deikus Gintaras¹²,Lewis-Sandari Martha¹²,Khan Zenab¹²,Beckford Colleen¹²,Rendo Angela⁴,Samaroo Flora⁴,Sebra Robert¹²,Karam-Howlin Ramona³,Dingle Tanis⁴,Hamula Camille⁴,Bashir Ali¹²,Schadt Eric¹²,Patel Gopi³,Wallach Frances⁵,Kasarskis Andrew¹²,Gibbs Kathleen⁶,van Bakel Harm¹²^ORCID

Affiliation:

1. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

2. Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

3. Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

4. Department of Pathology, Clinical Microbiology, Icahn School of Medicine at Mount Sinai, New York City, New York, USA

5. Department of Medicine, Division of Infectious Diseases, Northwell Long Island Jewish Medical Center, New Hyde Park, New York, USA

6. Division of Neonatology and Department of Pediatrics, The Children’s Hospital of Philadelphia, The University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Whole-genome sequencing (WGS) of Staphylococcus aureus is increasingly used as part of infection prevention practices. In this study, we established a long-read technology-based WGS screening program of all first-episode methicillin-resistant Staphylococcus aureus (MRSA) blood infections at a major urban hospital.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Icahn School of Medicine at Mount Sinai

New York State Department of Health

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01261-19

Reference68 articles.

1. Invasive Methicillin-Resistant Staphylococcus aureus Infections in the United States