Simultaneous Infection with Enterobacteriaceae and Pseudomonas aeruginosa Harboring Multiple Carbapenemases in a Returning Traveler Colonized with Candida auris-Reference-Cited by-同舟云学术

Simultaneous Infection with Enterobacteriaceae and Pseudomonas aeruginosa Harboring Multiple Carbapenemases in a Returning Traveler Colonized with Candida auris

Published:2020-01-27 Issue:2 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Khan Ayesha¹²³,Shropshire William C.¹⁴,Hanson Blake¹⁵⁴,Dinh An Q.¹⁵,Wanger Audrey¹⁵⁶,Ostrosky-Zeichner Luis¹⁵,Arias Cesar A.¹³⁵⁴⁷,Miller William R.¹⁵^ORCID

Affiliation:

1. Center for Antimicrobial Resistance and Microbial Genomics, University of Texas Health Science Center, McGovern School of Medicine, Houston, Texas, USA

2. Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, McGovern School of Medicine, Houston, Texas, USA

3. MD Anderson Cancer Center and UT Health Graduate School of Biomedical Sciences, University of Texas Health Science Center, McGovern School of Medicine, Houston, Texas, USA

4. Center for Infectious Diseases, University of Texas Health Science Center, School of Public Health, Houston, Texas, USA

5. Division of Infectious Diseases, University of Texas Health Science Center, McGovern School of Medicine, Houston, Texas, USA

6. Department of Pathology and Laboratory Medicine, University of Texas Health Science Center, McGovern School of Medicine, Houston, Texas, USA

7. Molecular Genetics and Antimicrobial Resistance Unit, International Center for Microbial Genomics, Universidad El Bosque, Bogotá, Colombia

Abstract

We report our clinical experience treating a critically ill patient with polymicrobial infections due to multidrug-resistant Escherichia coli , Klebsiella pneumoniae , and Pseudomonas aeruginosa in a 56-year-old woman who received health care in India and was also colonized by Candida auris . A precision medicine approach using whole-genome sequencing revealed a multiplicity of mobile elements associated with NDM-1, NDM-5, and OXA-181 and, supplemented with susceptibility testing, guided the selection of rational antimicrobial therapy.

Funder

Texas Medical Center

HHS | National Institutes of Health

University of Texas Health Science Center at Houston

University of Texas System

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01466-19

Reference20 articles.