Time to earliest peak serum antibody response to influenza vaccine in the elderly

Author:

Gross P A1,Russo C1,Dran S1,Cataruozolo P1,Munk G1,Lancey S C1

Affiliation:

1. Department of Internal Medicine, Hackensack University Medical Center, New Jersey 07601, USA.

Abstract

The earliest time at which serum antibody levels peak following administration of an influenza virus vaccine in elderly persons is not clearly defined. We compared the time intervals of 1 and 2 weeks after vaccination. A commercial trivalent vaccine containing the hemagglutinins of influenza viruses A/Texas/36/91 (H1N1), A/Johannesburg/33/94 (H3N2), and B/Harbin/7/94 was used. The hemagglutination inhibition (HAI) antibody titers at 1 week after vaccination were significantly lower than the HAI titers at 2 weeks postvaccination for all three vaccine components.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Reference9 articles.

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5. Neutralization test in influenza: use in individuals without hemagglutination inhibition antibody;Gross P. A.;J. Clin. Microbiol.,1979

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