Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin-Reference-Cited by-同舟云学术

Pyrogenicity and Immunogenicity of Lipid A Complexed with Bovine Serum Albumin or Human Serum Albumin

Published:1973-08 Issue:2 Volume:8 Page:173-177
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Rietschel E. T.¹²,Kim Y. B.¹²,Watson D. W.¹²,Galanos C.¹²,Lüderitz O.¹²,Westphal O.¹²

Affiliation:

1. Department of Microbiology, University of Minnesota, Minneapolis, Minnesota 55455

2. Max-Planck-Institut für Immunbiologie, D-78 Freiburg i. Br., Germany

Abstract

The lipid A component of bacterial lipopolysaccharides (endotoxins), when complexed to bovine serum albumin (BSA) or human serum albumin (HSA), was shown to be a potent pyrogen. Furthermore, rabbits could be protected against endotoxin fever by immunization with both lipid A·BSA and lipid A·HSA complexes. The results presented in this paper show that lipid A is responsible for the pyrogenic activity of endotoxins and their ability to induce pyrogenic immunity.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.8.2.173-177.1973

Reference22 articles.

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4. Interaction of lipopolysaccharides and lipid A with complement;Galanos C.;Eur. J. Biochem.,1971

5. Biological activities of lipid A complexed with bovine serum albumin;Galanos C.;Eur. J. Biochem.,1972

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