Safety of Oral Vancomycin in Functionally Anephric Patients

Author:

Bryan Charles S.1,White Wain L.1

Affiliation:

1. University of South Carolina School of Medicine and Richland Memorial Hospital, Columbia, South Carolina 29203

Abstract

Administration of a vancomycin oral solution, 2 g daily for 16 days, to functionally anephric patients without inflammatory bowel disease resulted in assayable but low (≤0.66 μg/ml) serum levels in two of the five volunteers.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference8 articles.

1. Clindamycin-associated colitis in hamsters: protection with vancomycin;Bartlett J. G.;Gastroenterology,1977

2. Simplified, accurate method for antibiotic assay of clinical specimens;Bennett J. V.;Appl. Microbiol.,1966

3. The protective effect of vancomycin on cindamycin-induced colitis in hamsters;Browne R. A.;Johns Hopkins Med. J.,1977

4. Vancomycin revisited;Cook F. V.;Ann. Intern. Med.,1978

5. Some laboratory and clinical experiences with a new antibiotic, vancomycin;Geraci J. E.;Proc. Staff Meet. Mayo Clin.,1956

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