Unraveling the Microbiome of Necrotizing Enterocolitis: Insights in Novel Microbial and Metabolomic Biomarkers-Reference-Cited by-同舟云学术

Unraveling the Microbiome of Necrotizing Enterocolitis: Insights in Novel Microbial and Metabolomic Biomarkers

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Tarracchini Chiara¹,Milani Christian¹²^ORCID,Longhi Giulia¹³,Fontana Federico¹³,Mancabelli Leonardo¹,Pintus Roberta⁴,Lugli Gabriele Andrea¹,Alessandri Giulia¹,Anzalone Rosaria³,Viappiani Alice³,Turroni Francesca¹²^ORCID,Mussap Michele⁴,Dessì Angelica⁴,Cesare Marincola Flaminia⁵,Noto Antonio⁶,De Magistris Anna⁴,Vincent Marine⁷⁸,Bernasconi Sergio²,Picaud Jean-Charles⁷⁸,Fanos Vassilios⁴⁹,Ventura Marco¹²^ORCID

Affiliation:

1. Laboratory of Probiogenomics, Department of Chemistry, Life Sciences, and Environmental Sustainability, University of Parma, Parma, Italy

2. Microbiome Research Hub, University of Parma, Parma, Italy

3. GenProbio Srl, Parma, Italy

4. Neonatal Intensive Care Unit, Department of Surgical Sciences, University of Cagliari, Monserrato, Italy

5. Department of Chemical and Geological Sciences, University of Cagliari, Monserrato, Cagliari, Italy

6. Department of Medical Science and Public Health, University of Cagliari, Monserrato, Cagliari, Italy

7. Neonatology Unit, Croix-Rousse University Hospital, Hospices Civils de Lyon, Lyon, France

8. CarMen laboratory, INSERM, INRA, Claude Bernard University Lyon, Pierre Benite, France

9. Neonatal Intensive Care Unit, AOU, University of Cagliari, Cagliari, Italy

Abstract

Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease occurring predominantly in premature infants whose etiology is still not fully understood. In this study, the analysis of infant fecal samples through shotgun metagenomics approaches revealed a marked reduction of the intestinal (bio)diversity and an overgrowth of (opportunistic) pathogens associated with the NEC development.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.01176-21

Reference83 articles.

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2. Necrotizing Enterocolitis

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4. Evolution of Gut Microbiome and Metabolome in Suspected Necrotizing Enterocolitis: A Case-Control Study

5. The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota

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