Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy-Reference-Cited by-同舟云学术

Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Tanner Lloyd¹^ORCID,Mashabela Gabriel T.²,Omollo Charles C.²,de Wet Timothy J.²,Parkinson Christopher J.³,Warner Digby F.²⁴^ORCID,Haynes Richard K.⁵^ORCID,Wiesner Lubbe¹^ORCID

Affiliation:

1. Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa

2. SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, Department of Pathology and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

3. School of Biomedical Sciences, Charles Sturt University, Orange, New South Wales, Australia

4. Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa

5. Centre of Excellence for Pharmaceutical Sciences, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa

Abstract

This study addresses the development of novel therapeutic compounds for the eventual treatment of drug-resistant tuberculosis. Tuberculosis continues to progress, with cases of Mycobacterium tuberculosis ( M. tuberculosis ) resistance to first-line medications increasing.

Funder

National Research Foundation

South African Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00434-21

Reference118 articles.

1. WHO. 2020. Global tuberculosis report 2020. World Health Organization, Geneva, Switzerland.

2. Tuberculosis eradication versus control