Limited Value of Single Sampling for IgM Antibody Determination as a Diagnostic Approach for Acute Hepatitis E Virus Infection-Reference-Cited by-同舟云学术

Limited Value of Single Sampling for IgM Antibody Determination as a Diagnostic Approach for Acute Hepatitis E Virus Infection

Published:2021-09-03 Issue:1 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Rivero-Juarez Antonio¹^ORCID,Lopez-Lopez Pedro¹,Pineda Juan Antonio²,Alados Juan Carlos³,Fuentes-López Ana⁴⁵,Ramirez-Arellano Encarnación⁶⁷,Freyre Carolina⁸,Perez Ana Belén⁹,Frias Mario¹,Rivero Antonio¹

Affiliation:

1. Unit of Infectious Diseases, Hospital Universitario Reina Sofia, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain

2. Unit of Infectious Diseases and Microbiology, Hospital Universitario de Valme, Seville, Spain

3. Clinical Microbiology Unit, Hospital Universitario de Jerez, Cádiz, Spain

4. Clinical Microbiology Unit, Hospital Universitario Clínico San Cecilio, Granada, Spain

5. Instituto de Investigacion Biosanitaria Ibs.Granada, Granada, Spain

6. Infectious Diseases, Microbiology and Preventive Medicine Unit, Virgen Macarena University Hospital, University of Seville/Biomedicine Institute of Seville, Seville, Spain

7. Department of Medicine, University of Seville/Biomedicine Institute of Seville, Seville, Spain

8. Clinical Microbiology Unit, University Hospital of Puerto Real, Cádiz, Spain

9. Clinical Microbiology Unit, Hospital Universitario Reina Sofía, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain

Abstract

In immunocompetent patients with a suspicion of hepatitis E virus (HEV) infection, single IgM antibody testing is typically applied. In this prospective study, we aimed to evaluate the accuracy of three different HEV screening approaches in patients with acute hepatitis, including approaches based on IgM determination, HEV RNA detection, and the combination of both.

Funder

MEC | Instituto de Salud Carlos III

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00382-21

Reference11 articles.

1. EASL Clinical Practice Guidelines on hepatitis E virus infection

2. European Centre for Disease Prevention and Control. 2019. Options for national testing and surveillance for hepatitis E virus in the EU/EEA—operational guidance. ECDC, Stockholm, Sweden. https://www.ecdc.europa.eu/sites/default/files/documents/hepatitis-e-guidance.pdf.

3. Executive summary: Consensus document of the diagnosis, management and prevention of infection with the hepatitis E virus: Study Group for Viral Hepatitis (GEHEP) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)

4. Screening, diagnosis and risks associated with Hepatitis E virus infection

5. Hepatitis E Virus Infection

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