Transport of an Antifungal Trypsin Inhibitor Isolated from Corn across the Blood-Brain Barrier-Reference-Cited by-同舟云学术

Transport of an Antifungal Trypsin Inhibitor Isolated from Corn across the Blood-Brain Barrier

Published:2002-08 Issue:8 Volume:46 Page:2633-2635
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Banks William A.¹²,Niehoff Michael L.¹²,Brown Robert L.³,Chen Zhi-Yuan⁴,Cleveland Thomas E.³

Affiliation:

1. Geriatric Research, Educational, and Clinical Center, Veterans Affairs Medical CenterDivision of Geriatrics, Department of Internal Medicine

2. Saint Louis University School of Medicine, St. Louis, Missouri

3. Agricultural Research Service, New Orleans

4. Department of Plant Pathology and Crop Physiology, Louisiana State University, Baton Rouge, Louisiana

Abstract

ABSTRACT We determined whether an antifungal 14-kDa protein trypsin inhibitor isolated from corn is able to cross the blood-brain barrier. We found that it completely crossed the blood-brain barrier by means of a saturable mechanism at a rate of 0.153 μl/g · min, with about 0.082% of the intravenously injected dose being taken up per gram of brain.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.46.8.2633-2635.2002

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