Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen-Reference-Cited by-同舟云学术

Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen

Published:1993-06 Issue:6 Volume:67 Page:3696-3701
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Borisova G¹,Arya B¹,Dislers A¹,Borschukova O¹,Tsibinogin V¹,Skrastina D¹,Eldarov M A¹,Pumpens P¹,Skryabin K G¹,Grens E¹

Affiliation:

1. Institute of Molecular Biology, Latvian Academy of Sciences, Riga.

Abstract

A hepatitis B core antigen (HBcAg) gene bearing the 39-amino-acid-long domain A of hepatitis B surface antigen (HBsAg) within the HBcAg immunodominant loop has been constructed and expressed in Escherichia coli. Chimeric capsids demonstrated HBs but not HBc antigenicity and elicited in mice B-cell and T-cell responses against native HBcAg and HBsAg.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.67.6.3696-3701.1993

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