Prevalence of Aminoglycoside Resistance Genes and Molecular Characterization of a Novel Gene, aac(3)-IIg , among Clinical Isolates of the Enterobacter cloacae Complex from a Chinese Teaching Hospital-Reference-Cited by-同舟云学术

Prevalence of Aminoglycoside Resistance Genes and Molecular Characterization of a Novel Gene, aac(3)-IIg , among Clinical Isolates of the Enterobacter cloacae Complex from a Chinese Teaching Hospital

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Zhu Xinyi¹²³,Li Peizhen²,Qian Changrui²,Liu Hongmao¹²,Lin Hailong²⁴,Zhang Xueya²⁴,Li Qiaoling²⁴,Lu Junwan²,Lin Xi²,Xu Teng⁵,Zhang Hailin²⁴,Hu Yunliang¹²,Bao Qiyu²⁴,Li Kewei²⁴^ORCID

Affiliation:

1. Department of Laboratory Sciences, the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China

2. Key Laboratory of Medical Genetics of Zhejiang Province, Key Laboratory of Laboratory Medicine, Ministry of Education, China, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China

3. Center of Prenatal Diagnosis, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, China

4. Department of Children’s Respiratory Disease, the Second Affiliated Hospital and Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, China

5. Institute of Translational Medicine, Baotou Central Hospital, Baotou, China

Abstract

Members of the Enterobacter cloacae complex are important opportunistic human pathogens capable of causing a wide variety of infections. During recent decades, aminoglycoside-resistant E. cloacae complex isolates have increasingly been reported and have become a major concern. Here, we employed high-throughput sequencing in combination with specific PCR assays to investigate the prevalence of aminoglycoside resistance genes among 170 isolates of the E. cloacae complex collected from a teaching hospital in Wenzhou, China.

Funder

Science and Technology Project of Inner Mongolia Autonomous Region, China

National Natural Science Foundation of China

Natural Science Foundation of Zhejiang Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00852-20

Reference54 articles.

1. Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation