Population Genomics of emm4 Group A Streptococcus Reveals Progressive Replacement with a Hypervirulent Clone in North America-Reference-Cited by-同舟云学术

Population Genomics of emm4 Group A Streptococcus Reveals Progressive Replacement with a Hypervirulent Clone in North America

Published:2021-08-31 Issue:4 Volume:6 Page:
ISSN:2379-5077
Container-title:mSystems
language:en
Short-container-title:mSystems

Author:

DebRoy Sruti¹,Sanson Misu²,Shah Brittany²,Regmi Shirjana²,Vega Luis Alberto²,Odo Chioma¹,Sahasrabhojane Pranoti¹,McGeer Allison³⁴,Tyrrell Gregory J.⁵⁶,Fittipaldi Nahuel⁴⁷,Shelburne Samuel A.¹⁸⁹,Flores Anthony R.²⁹^ORCID

Affiliation:

1. Department of Infectious Diseases Infection Control and Employee Health, MD Anderson Cancer Center, Houston, Texas, USA

2. Division of Infectious Diseases, Department of Pediatrics, University of Texas Health Science Center, McGovern Medical School, Houston, Texas, USA

3. Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada

4. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada

5. Alberta Public Health Laboratories, Public Health–Alberta Health Services, Edmonton, Alberta, Canada

6. Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada

7. Public Health Ontario Laboratory, Toronto, Ontario, Canada

8. Department of Genomic Medicine, MD Anderson Cancer Center, Houston, Texas, USA

9. Center for Antimicrobial Resistance and Microbial Genomics, University of Texas Health Science Center McGovern Medical School, Houston, Texas, USA

Abstract

Severe invasive infections caused by group A Streptococcus (GAS) result in substantial morbidity and mortality in children and adults worldwide. Previously, GAS clonal strain replacement has been attributed to acquisition of exogenous DNA leading to novel virulence gene acquisition or increased virulence gene expression.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Computer Science Applications,Genetics,Molecular Biology,Modeling and Simulation,Ecology, Evolution, Behavior and Systematics,Biochemistry,Physiology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mSystems.00495-21

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