Unraveling of a Neutralization Mechanism by Two Human Antibodies against Conserved Epitopes in the Globular Head of H5 Hemagglutinin-Reference-Cited by-同舟云学术

Unraveling of a Neutralization Mechanism by Two Human Antibodies against Conserved Epitopes in the Globular Head of H5 Hemagglutinin

Published:2013-03-15 Issue:6 Volume:87 Page:3571-3577
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Qian Mengran¹,Hu Hongxing¹,Zuo Teng²,Wang Guiqin¹,Zhang Linqi²,Zhou Paul¹

Affiliation:

1. The Unit of Anti-Viral Immunity and Genetic Therapy, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China

2. Comprehensive AIDS Research Center, School of Medicine, Tsinghua University, Beijing, China

Abstract

ABSTRACT The rapid spread of highly pathogenic avian influenza (HPAI) H5N1 virus underscores the importance of effective antiviral treatment. Previously, we developed human monoclonal antibodies 65C6 and 100F4 that neutralize almost all (sub)clades of HPAI H5N1. The conserved 65C6 epitope was mapped to the globular head of HA. However, neither the 100F4 epitope nor the neutralization mechanism by these antibodies was known. In this study, we determined the 100F4 epitope and unraveled a neutralization mechanism by antibodies 65C6 and 100F4.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01292-12

Reference37 articles.

1. A Human Antibody Recognizing a Conserved Epitope of H5 Hemagglutinin Broadly Neutralizes Highly Pathogenic Avian Influenza H5N1 Viruses

2. Comprehensive analysis of pathogen-specific antibody response in vivo based on an antigen library displayed on surface of yeast;Zuo T;J. Biol. Chem.,2011

3. Measurement of neutralizing antibody responses against H5N1 clades in immunized mice and ferrets using pseudotypes expressing influenza hemagglutinin and neuraminidase

4. The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype)

5. Subtype- and antigenic site-specific differences in biophysical influences on evolution of influenza virus hemagglutinin

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