Staphylococcus aureus Does Not Synthesize Arginine from Proline under Physiological Conditions

Author:

Jeong Bohyun12,Shah Majid Ali2,Roh Eunjung3,Kim Kyeongkyu4,Park Indal1,Bae Taeok2ORCID

Affiliation:

1. Department of Microbiology, Research Institute for Antimicrobial Resistance, Kosin University College of Medicine, Busan, South Korea

2. Department of Microbiology and Immunology, Indiana University School of Medicine-Northwest, Gary, Indiana, USA

3. Crop Protection Division, National Institute of Agricultural Sciences, Rural Development Administration, Wanju-gun, South Korea

4. Department of Precision Medicine, Sungkyunkwan University School of Medicine, SMC, Suwon, South Korea

Abstract

Staphylococcus aureus is a versatile Gram-positive human pathogen infecting various human organs. The bacterium's versatility is partly due to efficient metabolic regulation via the carbon catabolite repression system (CCR). S. aureus is known to interconvert proline and arginine, and CCR represses the synthesis of both amino acids.

Funder

HHS | National Institutes of Health

Ministry of Health and Welfare

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

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