HIV-1 Gag Recruits Oligomeric Vpr via Two Binding Sites in p6, but Both Mature p6 and Vpr Are Rapidly Lost upon Target Cell Entry-Reference-Cited by-同舟云学术

HIV-1 Gag Recruits Oligomeric Vpr via Two Binding Sites in p6, but Both Mature p6 and Vpr Are Rapidly Lost upon Target Cell Entry

Published:2021-08-10 Issue:17 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wanaguru Madushi¹,Bishop Kate N.¹^ORCID

Affiliation:

1. Retroviral Replication Laboratory, The Francis Crick Institute, London, United Kingdom

Abstract

The p12 protein of MLV and the p6 protein of HIV-1 are both supplementary Gag cleavage products that carry proline-rich motifs that facilitate virus budding. Importantly, p12 has also been found to be essential for early viral replication events.

Funder

Cancer Research UK

UKRI | Medical Research Council

Wellcome

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.00554-21

Reference64 articles.

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5. HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway

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