Antagonistic Effect of Colistin on Vancomycin Activity against Methicillin-Resistant Staphylococcus aureus in In Vitro and In Vivo Studies-Reference-Cited by-同舟云学术

Antagonistic Effect of Colistin on Vancomycin Activity against Methicillin-Resistant Staphylococcus aureus in In Vitro and In Vivo Studies

Published:2020-03-24 Issue:4 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Choi Sungim¹²,Moon Song Mi³,Park Su-Jin⁴,Lee Seung Cheol⁵,Jung Kyung Hwa¹,Sung Heung-sup⁶^ORCID,Kim Mi-Na⁶^ORCID,Jung Jiwon¹,Kim Min Jae¹,Kim Sung-Han¹,Lee Sang-Oh¹^ORCID,Choi Sang-Ho¹,Jeong Jin-Yong⁷,Woo Jun Hee¹,Kim Yang Soo¹,Chong Yong Pil¹

Affiliation:

1. Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

2. Department of Infectious Diseases, Dongguk University Ilsan Hospital, Goyang, Republic of Korea

3. Division of Infectious Diseases, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang-si, Gyeonggi-do, Republic of Korea

4. Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan College of Medicine, Seoul, Republic of Korea

5. Department of Infectious Diseases and Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

6. Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

7. Department of Convergence Medicine and Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

Abstract

As concerns arise that the vancomycin MIC of methicillin-resistant Staphylococcus aureus (MRSA) could be increased by concurrent colistin administration, we evaluated the effect of colistin on vancomycin efficacy against MRSA via in vitro and in vivo studies. Among MRSA blood isolates collected in a tertiary-care hospital, we selected representative strains from community-associated MRSA strains (CA-MRSA; ST72-MRSA-SCC mec IV) and hospital-acquired MRSA strains (HA-MRSA; ST5-MRSA-SCC mec II).

Funder

Ministry of Education

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01925-19

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