A Novel Running Wheel Mouse Model for Botulism and Its Use for the Evaluation of Postsymptom Antitoxin Efficacy-Reference-Cited by-同舟云学术

A Novel Running Wheel Mouse Model for Botulism and Its Use for the Evaluation of Postsymptom Antitoxin Efficacy

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Schwartz Arieh¹,Ben David Alon¹,Hotoveli Mordechai²,Dor Eyal¹,Diamant Eran¹,Vivyorka Arik³,Rosen Osnat¹,Torgeman Amram¹,Zichel Ran¹^ORCID

Affiliation:

1. Department of Biotechnology, Israel Institute for Biological Research, Ness Ziona, Israel

2. Department of Environmental Physics, Israel Institute for Biological Research, Ness Ziona, Israel

3. Division of Operations & Infrastructure, Israel Institute for Biological Research, Ness Ziona, Israel

Abstract

Antitoxin is currently the only approved therapy for botulinum intoxications. The efficacy of antitoxin preparations is evaluated in animals. However, while in practice antitoxin is administered to patients only after symptom onset, in most animal studies, it is tested in relation to time postintoxication.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00421-21

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