A Novel Running Wheel Mouse Model for Botulism and Its Use for the Evaluation of Postsymptom Antitoxin Efficacy

Author:

Schwartz Arieh1,Ben David Alon1,Hotoveli Mordechai2,Dor Eyal1,Diamant Eran1,Vivyorka Arik3,Rosen Osnat1,Torgeman Amram1,Zichel Ran1ORCID

Affiliation:

1. Department of Biotechnology, Israel Institute for Biological Research, Ness Ziona, Israel

2. Department of Environmental Physics, Israel Institute for Biological Research, Ness Ziona, Israel

3. Division of Operations & Infrastructure, Israel Institute for Biological Research, Ness Ziona, Israel

Abstract

Antitoxin is currently the only approved therapy for botulinum intoxications. The efficacy of antitoxin preparations is evaluated in animals. However, while in practice antitoxin is administered to patients only after symptom onset, in most animal studies, it is tested in relation to time postintoxication.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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