Sequence-Based Epidemiology of an OXA-48 Plasmid during a Hospital Outbreak

Author:

Hidalgo Laura1,de Been Mark1,Rogers Malbert R. C.1,Schürch Anita C.1,Scharringa Jelle1,van der Zee Anneke2ORCID,Bonten Marc J. M.13,Fluit Ad C.1

Affiliation:

1. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

2. Molecular Diagnostics Unit, Maasstad Hospital, Rotterdam, The Netherlands

3. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

Abstract

A large OXA-48 outbreak in The Netherlands involved the spread of OXA-48-producing Enterobacteriaceae among at least 118 patients, suggesting horizontal transfer of this resistance gene through one or more plasmids. Elucidating transmission dynamics of resistance plasmids is hampered by the low resolution of classic typing methods. This study aimed to investigate the molecular epidemiology of plasmids carrying the OXA-48 carbapenemase using a next-generation sequencing approach.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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