Sequence-Based Epidemiology of an OXA-48 Plasmid during a Hospital Outbreak-Reference-Cited by-同舟云学术

Sequence-Based Epidemiology of an OXA-48 Plasmid during a Hospital Outbreak

Published:2019-12 Issue:12 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hidalgo Laura¹,de Been Mark¹,Rogers Malbert R. C.¹,Schürch Anita C.¹,Scharringa Jelle¹,van der Zee Anneke²^ORCID,Bonten Marc J. M.¹³,Fluit Ad C.¹

Affiliation:

1. Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

2. Molecular Diagnostics Unit, Maasstad Hospital, Rotterdam, The Netherlands

3. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

Abstract

A large OXA-48 outbreak in The Netherlands involved the spread of OXA-48-producing Enterobacteriaceae among at least 118 patients, suggesting horizontal transfer of this resistance gene through one or more plasmids. Elucidating transmission dynamics of resistance plasmids is hampered by the low resolution of classic typing methods. This study aimed to investigate the molecular epidemiology of plasmids carrying the OXA-48 carbapenemase using a next-generation sequencing approach.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01204-19

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