Antibacterial activities of the antiparasitic drugs nifurtimox and benznidazole-Reference-Cited by-同舟云学术

Antibacterial activities of the antiparasitic drugs nifurtimox and benznidazole

Published:1989-03 Issue:3 Volume:33 Page:404-405
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Hof H¹

Affiliation:

1. Institute of Medical Microbiology and Hygiene, University of Heidelberg, Faculty of Clinical Medicine Mannheim, Federal Republic of Germany.

Abstract

Both nifurtimox and benznidazole, which are used for the treatment of Chagas' disease, also display marked antibacterial activities. Characteristically for nitroheterocyclic compounds, they are much more active against anaerobic and microaerophilic bacteria than against aerobic bacteria. Nitroreductase-deficient aerobes are completely resistant, whereas SOS-repair-deficient strains are moderately susceptible. Those strains are rapidly killed.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.33.3.404

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