A New Phenotype in <i>Candida</i> -Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis-Associated Strains-Reference-Cited by-同舟云学术

A New Phenotype in Candida -Epithelial Cell Interaction Distinguishes Colonization- versus Vulvovaginal Candidiasis-Associated Strains

Published:2023-04-25 Issue:2 Volume:14 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Sala Arianna¹^ORCID,Ardizzoni Andrea¹,Spaggiari Luca²^ORCID,Vaidya Nikhil³,van der Schaaf Jane³,Rizzato Cosmeri⁴,Cermelli Claudio¹,Mogavero Selene⁵,Krüger Thomas⁶,Himmel Maximilian⁵,Kniemeyer Olaf⁶,Brakhage Axel A.⁶^ORCID,King Benjamin L.³⁷,Lupetti Antonella⁴^ORCID,Comar Manola⁸⁹,de Seta Francesco⁸⁹,Tavanti Arianna¹⁰,Blasi Elisabetta¹^ORCID,Wheeler Robert T.³⁷^ORCID,Pericolini Eva¹^ORCID

Affiliation:

1. Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy

2. Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy

3. Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA

4. Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

5. Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Jena, Germany

6. Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute (HKI), Jena, Germany

7. Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, Maine, USA

8. Institute for Maternal and Child Health—IRCCS Burlo Garofolo, Trieste, Italy

9. Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy

10. Department of Biology, University of Pisa, Pisa, Italy

Abstract

Despite a high incidence of VVC, we still have a poor understanding of this female-specific disease whose negative impact on women’s quality of life has become a public health issue. It is not yet possible to determine by genotype or laboratory phenotype if a given Candida albicans strain is more or less likely to cause VVC.

Funder

FAR

Burroughs Wellcome Fund

Deutsche Forschungsgemeinschaft

HHS | National Institutes of Health

U.S. Department of Agriculture

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mbio.00107-23