Preclinical Data on the <i>Gardnerella</i> -Specific Endolysin PM-477 Indicate Its Potential to Improve the Treatment of Bacterial Vaginosis through Enhanced Biofilm Removal and Avoidance of Resistance-Reference-Cited by-同舟云学术

Preclinical Data on the Gardnerella -Specific Endolysin PM-477 Indicate Its Potential to Improve the Treatment of Bacterial Vaginosis through Enhanced Biofilm Removal and Avoidance of Resistance

Published:2022-05-17 Issue:5 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Landlinger Christine¹^ORCID,Oberbauer Vera¹^ORCID,Podpera Tisakova Lenka¹^ORCID,Schwebs Timo¹,Berdaguer Rocío¹,Van Simaey Leen²,Vaneechoutte Mario²^ORCID,Corsini Lorenzo¹^ORCID

Affiliation:

1. BioNTech R&D (Austria) GmbH, Vienna, Austria

2. University of Ghent, Laboratory Bacteriology Research, Department of Diagnostic Sciences, Faculty of Medicine & Health Sciences, Ghent, Belgium

Abstract

Antibiotics are the mainstay of therapy for bacterial vaginosis (BV). However, the rate of treatment failure in patients with recurrent BV is about 50%.

Funder

Austrian FFG

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.02319-21

Reference52 articles.

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2. Bacterial vaginosis: a synthesis of the literature on etiology, prevalence, risk factors, and relationship with chlamydia and gonorrhea infections

3. The global epidemiology of bacterial vaginosis: a systematic review