Levofloxacin and Ciprofloxacin Decrease Procainamide and N -Acetylprocainamide Renal Clearances-Reference-Cited by-同舟云学术

Levofloxacin and Ciprofloxacin Decrease Procainamide and N -Acetylprocainamide Renal Clearances

Published:2005-04 Issue:4 Volume:49 Page:1649-1651
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bauer Larry A.¹²,Black Douglas J.¹,Lill Jennifer S.³,Garrison Julie³,Raisys Vidmantas A.²,Hooton Thomas M.⁴

Affiliation:

1. Department of Pharmacy, University of Washington, Seattle, Washington

2. Department of Laboratory Medicine, University of Washington, Seattle, Washington

3. Department of Pharmacy Services, University of Washington, Seattle, Washington

4. Department of Medicine, University of Washington, Seattle, Washington

Abstract

ABSTRACT Ten healthy adults participated in a randomized, crossover drug interaction study testing procainamide only, procainamide plus levofloxacin, and procainamide plus ciprofloxacin. During levofloxacin therapy, most procainamide and N -acetylprocainamide (NAPA) pharmacokinetic parameters, including decreased renal clearances and renal clearance/creatinine clearance ratios, changed ( P < 0.05). During ciprofloxacin treatment, only procainamide and NAPA renal clearances decreased significantly.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.4.1649-1651.2005

Reference21 articles.

1. al-Khamis, K. I., L. K. Jim, S. A. Bawazir, L. F. Ashour, N. el-Sayed, and Y. M. el-Sayed. 1994. Effect of famotidine on ciprofloxacin pharmacokinetics after single intravenous and oral doses in rats. J. Clin. Pharm. Ther.19:335-339.

2. Alteration in the pharmacokinetic disposition of ciprofloxacin by simultaneous administration of azlocillin

3. Bauer L. A. 2001. Applied clinical pharmacokinetics 1st ed. p. 26-49. McGraw-Hill New York N.Y.

4. Bauer, L. A., D. Black, and A. Gensler. 1990. Procainamide-cimetidine drug interaction in elderly male patients. J. Am. Geriatr. Soc.38:467-469.

5. Bauer, L. A., D. Black, A. Gensler, and J. Sprinkle. 1989. Influence of age, renal function and heart failure on procainamide clearance and n-acetylprocainamide serum concentrations. Int. J. Clin. Pharmacol. Ther. Toxicol.27:213-216.

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