Human Dendritic Cells Transmit Enterovirus A71 via Heparan Sulfates to Target Cells Independent of Viral Replication-Reference-Cited by-同舟云学术

Human Dendritic Cells Transmit Enterovirus A71 via Heparan Sulfates to Target Cells Independent of Viral Replication

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Helgers Leanne C.¹²,Bhoekhan Michel S.¹²,Pajkrt Dasja³⁴,Wolthers Katja C.³⁴,Geijtenbeek Teunis B. H.¹²^ORCID,Sridhar Adithya²³⁴^ORCID

Affiliation:

1. Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

2. Amsterdam Institute for Infection and Immunity, Amsterdam, the Netherlands

3. Emma Children's Hospital, Department of Pediatric Infectious Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

4. Department of Medical Microbiology, OrganoVIR Labs, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Abstract

EV-A71 is an emerging neurotropic virus that is of emerging concern and can result in polio-like illness. The exact mechanism of how EV-A71 results in neurological symptoms are unknown.

Funder

EC | European Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

ZonMw

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02822-22

Reference27 articles.

1. Clinical features, diagnosis, and management of enterovirus 71

2. Acute Flaccid Paralysis and Enteroviral Infections

3. Understanding Enterovirus 71 Neuropathogenesis and Its Impact on Other Neurotropic Enteroviruses

4. Enterovirus 71 infection and neurological complications

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