Three Amino Acid Substitutions in the Spike Protein Enable the Coronavirus Porcine Epidemic Diarrhea Virus To Infect Vero Cells

Author:

Chen Bingqing1,Dong Shijuan1,Yu Li1,Si Fusheng1,Li Chunhua1,Xie Chunfang1,Yu Ruisong1,Li Zhen1ORCID

Affiliation:

1. Institute of Animal Husbandry and Veterinary Science, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Engineering Research Center of Breeding Pig, Shanghai Academy of Agricultural Sciences, Shanghai, China

Abstract

Porcine epidemic diarrhea virus (PEDV) is a lethal pathogen for newborn piglets, and an efficient vaccine is needed urgently. However, propagating wild-type PEDV in cultured cells for vaccine development is still challenging due to the lack of knowledge about the mechanism of the cell adaptation of PEDV.

Funder

Science and Technology Innovation Plan Of Shanghai Science and Technology Commission

MOST | International Science and Technology Cooperation Programme

Shanghai Academy of Agricultural Sciences

Shanghai Municipal Commission of Agriculture and Rural Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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