Epidemiological and Genetic Characteristics of Clinical Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Strains in Guangdong Province, China-Reference-Cited by-同舟云学术

Epidemiological and Genetic Characteristics of Clinical Carbapenem-Resistant Pseudomonas aeruginosa Strains in Guangdong Province, China

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhao Yonggang¹,Chen Dingqiang²,Chen Kaichao³,Xie Miaomiao³^ORCID,Guo Jiubiao⁴,Chan Edward Wai Chi³,Xie Lu⁵,Wang Jingbo⁴,Chen Enqi⁴,Chen Sheng³^ORCID,Chen Weijun⁶,Jelsbak Lars¹^ORCID

Affiliation:

1. Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark

2. Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, People’s Republic of China

3. Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Kowloon, People’s Republic of China

4. College of Pharmacy-Shenzhen Technology University, Shenzhen, People’s Republic of China

5. Research Center for Micro-Ecological Agent Engineering and Technology of Guangdong Province, Guangzhou, People’s Republic of China

6. BGI-Shenzhen, Shenzhen, People’s Republic of China

Abstract

Carbapenem-resistant Pseudomonas aeruginosa (CRPA) is a major concern in clinical settings worldwide, yet few genetic and epidemiological studies on CRPA strains have been performed in China. Here, we sequence and analyze the genomes of 416 P. aeruginosa strains from hospitals in China to elucidate the genetic, phenotypic, and transmission characteristics of CRPA strains and to identify the molecular signatures responsible for the observed increase in the prevalence of CRPA infections in China.

Funder

Guangdong Major Project of Basic and Applied Basic Research

Danmarks Frie Forskningsfond

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04261-22

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