Helicobacter pylori Modulates Heptose Metabolite Biosynthesis and Heptose-Dependent Innate Immune Host Cell Activation by Multiple Mechanisms

Author:

Hauke Martina1,Metz Felix1,Rapp Johanna2,Faass Larissa1,Bats Simon H.1,Radziej Sandra3,Link Hannes2,Eisenreich Wolfgang3,Josenhans Christine1ORCID

Affiliation:

1. Max von Pettenkofer Institute, Ludwig Maximilians University Munich, München, Germany

2. Bacterial Metabolomics, CMFI, University Tübingen, Tübingen, Germany

3. Bavarian NMR Center–Structural Membrane Biochemistry, Department of Chemistry, Technical University Munich, Garching, Germany

Abstract

Bacterial heptose metabolites, intermediates of lipopolysaccharide (LPS) biosynthesis, are novel microbe-associated molecular patterns (MAMPs) that activate proinflammatory signaling. In the gastric pathogen Helicobacter pylori , heptoses are transferred into host cells by the Cag type IV secretion system, which is also involved in carcinogenesis.

Funder

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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