Helicobacter pylori Modulates Heptose Metabolite Biosynthesis and Heptose-Dependent Innate Immune Host Cell Activation by Multiple Mechanisms-Reference-Cited by-同舟云学术

Helicobacter pylori Modulates Heptose Metabolite Biosynthesis and Heptose-Dependent Innate Immune Host Cell Activation by Multiple Mechanisms

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Hauke Martina¹,Metz Felix¹,Rapp Johanna²,Faass Larissa¹,Bats Simon H.¹,Radziej Sandra³,Link Hannes²,Eisenreich Wolfgang³,Josenhans Christine¹^ORCID

Affiliation:

1. Max von Pettenkofer Institute, Ludwig Maximilians University Munich, München, Germany

2. Bacterial Metabolomics, CMFI, University Tübingen, Tübingen, Germany

3. Bavarian NMR Center–Structural Membrane Biochemistry, Department of Chemistry, Technical University Munich, Garching, Germany

Abstract

Bacterial heptose metabolites, intermediates of lipopolysaccharide (LPS) biosynthesis, are novel microbe-associated molecular patterns (MAMPs) that activate proinflammatory signaling. In the gastric pathogen Helicobacter pylori , heptoses are transferred into host cells by the Cag type IV secretion system, which is also involved in carcinogenesis.

Funder

Deutsche Forschungsgemeinschaft

Deutsches Zentrum für Infektionsforschung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03132-22

Reference61 articles.

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2. ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria

3. ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System

4. Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose

5. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity

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1. Trained Immunity and Trained Tolerance: The Case of Helicobacter pylori Infection;International Journal of Molecular Sciences;2024-05-28

2. Research progress on molecular mechanism of pyroptosis caused by Helicobacter pylori in gastric cancer;Annals of Medicine & Surgery;2024-02-15

3. Innate activation of human neutrophils and neutrophil-like cells by the pro-inflammatory bacterial metabolite ADP-heptose and Helicobacter pylori;International Journal of Medical Microbiology;2023-07