Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens-Reference-Cited by-同舟云学术

Functional and Structural Characterization of Diverse NfsB Chloramphenicol Reductase Enzymes from Human Pathogens

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Mullowney Michael W.¹^ORCID,Maltseva Natalia I.²³^ORCID,Endres Michael³,Kim Youngchang²³^ORCID,Joachimiak Andrzej²³⁴^ORCID,Crofts Terence S.⁵^ORCID

Affiliation:

1. Department of Chemistry, Northwestern University, Evanston, Illinois, USA

2. Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois, USA

3. Structure Biology Center, Argonne National Laboratory, Argonne, Illinois, USA

4. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA

5. Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA

Abstract

The question of how new enzyme activities evolve is of great biological interest and, in the context of antibiotic resistance, of great medical importance. Here, we have tested the hypothesis that new antibiotic resistance mechanisms may evolve from promiscuous housekeeping enzymes that have antibiotic modification side activities.

Funder

HHS | NIH | National Cancer Institute

HHS | NIH | National Institute of Allergy and Infectious Diseases

DOE | NNSA | LDRD | Argonne National Laboratory

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00139-22

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