Rationally Designed Minimal Bioactive Domains of AS-48 Bacteriocin Homologs Possess Potent Antileishmanial Properties

Author:

Corman Hannah N.12,Ross Jessica N.12ORCID,Fields Francisco R.3,Shoue Douglas A.12,McDowell Mary Ann12,Lee Shaun W.12ORCID

Affiliation:

1. University of Notre Dame, Department of Biological Sciences, Notre Dame, Indiana, USA

2. University of Notre Dame, Eck Institute for Global Health, Notre Dame, Indiana, USA

3. Johnson & Johnson Consumer Products Inc., Skillman, New Jersey, USA

Abstract

Leishmaniasis is a neglected tropical disease caused by protozoan parasites of the genus Leishmania . There are three primary clinical forms, cutaneous, mucocutaneous, and visceral, with visceral leishmaniasis being fatal if left untreated.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Indiana Clinical and Translational Sciences Institute

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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