Siderophore-Based Noninvasive Differentiation of Aspergillus fumigatus Colonization and Invasion in Pulmonary Aspergillosis-Reference-Cited by-同舟云学术

Siderophore-Based Noninvasive Differentiation of Aspergillus fumigatus Colonization and Invasion in Pulmonary Aspergillosis

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Luptáková Dominika¹,Patil Rutuja H.¹²,Dobiáš Radim³⁴,Stevens David A.⁵⁶,Pluháček Tomáš¹²,Palyzová Andrea¹,Káňová Marcela⁷⁸⁹,Navrátil Milan¹⁰,Vrba Zbyněk¹¹,Hubáček Petr¹²¹³,Havlíček Vladimír¹^ORCID

Affiliation:

1. Institute of Microbiology of the Czech Academy of Sciences, Prague, Czechia

2. Department of Analytical Chemistry, Palacký University, Olomouc, Czechia

3. Department of Bacteriology and Mycology, Public Health Institute in Ostrava, Ostrava, Czechia

4. Institute of Laboratory Medicine, Faculty of Medicine, University of Ostrava, Ostrava, Czechia

5. California Institute for Medical Research, San Jose, California, USA

6. Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California, USA

7. Department of Anesthesiology and Intensive Care Medicine, University Hospital Ostrava, Ostrava, Czechia

8. Institute of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, Ostrava, Czechia

9. Department of Intensive Medicine, Emergency Medicine and Forensic Studies, University of Ostrava, Ostrava, Czechia

10. Department of Hematooncology, University Hospital Ostrava, Ostrava, Czechia

11. Lung Department, Krnov Combined Medical Facility, Krnov, Czechia

12. Department of Medical Microbiology, Charles University, Prague, Czechia

13. Motol University Hospital, Prague, Czechia

Abstract

The importance of this research lies in the demonstration that siderophore analysis can distinguish between asymptomatic colonization and invasive pulmonary aspergillosis. We found clear associations between phases of fungal development, from conidial germination to the proliferative stage of invasive aspergillosis, and changes in secondary metabolite secretion.

Funder

Czech Science Foundation

Palacky University

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04068-22

Reference47 articles.

1. Aspergillus species in indoor environments and their possible occupational and public health hazards

2. Hybrid Imaging of Aspergillus fumigatus Pulmonary Infection with Fluorescent, 68Ga-Labelled Siderophores